Titlebook: Oligodeoxynucleotides; Antisense Inhibitors Jack S. Cohen Textbook 1989Latest edition Macmillan Publishers Limited 1989 cancer.cell.DNA.gen

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https://doi.org/10.1007/978-1-349-10869-5cancer; cell; DNA; gene; gene expression; genes; nucleic acid; nucleotide

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Macmillan Publishers Limited 1989

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Introduction: Strategies and Realities,m has blossomed to such an extent that it has now reached the stage of popularization (Chase, 1988; Kolata, 1988). But the basis for this approach, and the many assumptions and pitfalls involved in it, cannot be dealt with in a limited popular treatment.

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Phosphorothioate Oligodeoxynucleotide Analogues,Phosphorothioates contain a sulphur-for-oxygen substitution at phosphorus (Figure 5.1). In relation to the need for the development of chimeric oligo analogues for the antisense approach, the substitution of one sulphur atom for one oxygen atom is perhaps the most conservative chemical substitution that can be made at the phosphate moiety.

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