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Titlebook: Oligodeoxynucleotides; Antisense Inhibitors Jack S. Cohen Textbook 1989Latest edition Macmillan Publishers Limited 1989 cancer.cell.DNA.gen

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Textbook 1989Latest editionll areas of current knowledge and includes new results. The principle of the antisense approach is that an antisense mRNA base sequence will bind to its target mRNA base sequence and thus bring about the selective inhibition of gene expression. The antisense approach is important in general in under
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Textbook 1989Latest editionts target mRNA base sequence and thus bring about the selective inhibition of gene expression. The antisense approach is important in general in understanding gene function, and more specifically as a potential basis for new drugs, notably against cancer and viral genes.
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bind to its target mRNA base sequence and thus bring about the selective inhibition of gene expression. The antisense approach is important in general in understanding gene function, and more specifically as a potential basis for new drugs, notably against cancer and viral genes.
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Pharmaceutical Considerations,oach which was taken addresses principal issues, such as pharmacokinetics, ‘packaging’, targeting, toxicity and mutagenicity, either in an . manner, if experimental data were unavailable, or with reference to existing data for antisense oligomers, which were usually of a preliminary nature.
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