Titlebook: Voltage-gated Sodium Channels: Structure, Function and Channelopathies; Mohamed Chahine Book 2018 Springer International Publishing AG, pa

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Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspectiveion and its transmission from one location in the nervous system to another. In this review, we explore and compare structural and functional data from prokaryotic and eukaryotic channels to infer the effects of evolution on sodium channel structure and function.

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Sodium Channel Traffickingquality control could lead to the retention of functional VGSC and is therefore the target of different pharmacological approaches. The present chapter gives an overview of the current understanding of the facets of VGSC life cycle in the context of both cardiac and neuronal cell types.

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Structural Models of Ligand-Bound Sodium Channelsm channelopathies. Further summarized are sodium channel models with tetrodotoxin, mu-conotoxins, batrachotoxin, scorpion toxins, and insecticides. Possible involvement of sodium ions in the action of some ligands is discussed.

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Sodium Channelopathies of Skeletal Musclesis, congenital myasthenia, and congenital myopathy with hypotonia. Mutation-specific alternations of Na.1.4 function explain the mechanistic basis for the diverse phenotypes and identify opportunities for strategic intervention to modify the burden of disease.

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0171-2004 logical advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies..978-3-030-07982-6978-3-319-90284-5Series ISSN 0171-2004 Series E-ISSN 1865-0325

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The Cardiac Sodium Channel and Its Protein Partnersn into macromolecular complexes. The purpose of the present section is to provide an overview of the characterized partners of the main cardiac sodium channel, Na.1.5, involved in regulating the functional expression of this channel both in terms of trafficking and targeting into microdomains.

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Evolutionary History of Voltage-Gated Sodium Channelsn. The cells then utilize this transmembrane Na. concentration gradient as a driving force to produce electrical signals, sometimes in the form of action potentials. The protein family comprising voltage-gated sodium channels (Na.s) is essential for such signaling and enables cells to change their s

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