Titlebook: Vasoplegic Endothelial Dysfunction; Circulatory Shock an Paulo Roberto Barbosa Evora,Andrea Carla Celotto,P Book 2021 The Editor(s) (if app

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Endothelial Dysfunction in Hemorrhagic Shockresuscitation and survival to treat hypovolemic states. Also, a study in dogs was conducted to assess prehospital resuscitation after refractory hemorrhagic shock with a combination of MB and lactated Ringer’s limited volume solution. Since the early 1990s, studies have investigated nitric oxide (NO

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Endothelial Dysfunction in Cardiogenic Shockmic inflammatory response (SIRS), complement activation, inflammatory cytokines release, inducible nitric oxide synthase (iNOS) expression, and vasodilation would not solely have a crucial position in the shock genesis but also on its evolution. Nowadays, cardiogenic shock, a devastating final resul

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Methylene Bluecations, to date, regarding its safe use. Thus, its use does not mean the introduction of a new drug that implies scientific and ethical rigors. The toxic and therapeutic effects of MB are due to the interaction with the nitric oxide/cyclic guanosine 3′5′-cyclic monophosphate pathway (NO/cGMP). MB b

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The Inhibition of Guanylate Cyclase by?Methylene Blue as a Therapeutic Proposal of Vasoplegia Associyclic monophosphate (cGMP), and it has been described for nearly 40?years after its identification in mammalian cells. Nitric oxide (NO) was described in the late 1970s as responsible for its activation and, therefore, for the formation of cGMP. Ten years later, when the endothelium-derived relaxing

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Methylene Blue in the Treatment of Anaphylaxisg the importance of histamine in anaphylactic shock (ASh) mediation, since when released and transported by the bloodstream, it can produce an effect on the entire cardiovascular system, in addition to other tissues where histaminergic receptors can also be found. One of the hypotheses that could ex

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Methylene Blue in Children and Neonatestreatment of shock are overly aggressive, and patients in shock have worse results showing a higher incidence of serious sequelae, for example, intraventricular cerebral hemorrhage. The main cause of distributive shock in children, especially neonatal patients, is septic shock. Mortality in sepsis i

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Methylene Blue and Endocarditisammatory response because of infective endocarditis (IE) and those who need cardiopulmonary bypass (CPB) for emergency valve replacement may demonstrate resistant hypotension related to vasoplegia. It presents a spectrum of clinical presentation and is associated with a systemic inflammatory respons