Titlebook: Vascular Disruptive Agents for the Treatment of Cancer; Tim Meyer Book 2010 Springer Science+Business Media, LLC 2010 CT.angiogenesis.canc

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Martin Zweifel,Gordon Rustinrial toxins, such as those causing tetanus and diptheria, can facilitate the killing of pathogenic bacteria, and can protect against viral infection of cells. The ability to specifically immunize and provide protection against infectious disease has had a major impact on public health. Indeed a coor

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studies in their ability to answer important medical questions. Clinical trials are carried out under predetermined conditions, as defined in the treatment protocol. By specifying in this document the target group of patients, the treatment conditions, and the desired criteria of success or failure

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Grzegorz Korpanty,Rolf A. Brekkenharmaceuticals. With a significant higher number in clinical trials and the search for new recombinant proteins as a result of the human genome sequencing program it is expected that many more human antibodies will enter the market in years to come (Gura, 2002, Walsh, 2000).

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Tim MeyerThis book discusses preclinical target identification and validation, and the optimum pre-clinical animal models.Biomarkers and imaging modalities used to assess the efficacy of these agents are exami

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R. Barbara Pedley,Gillian M. TozerNephrotoxozit?t und Ototoxizit?t insbesondere bei langer Therapiedauer (> 10 Tage), hoher Dosierung (mehr als 15 g, > 32 μg/ml Spitzenspiegel, > 10 μg/ml Talspiegel), vorangegangener Aminoglycosid-Therapie und gleichzeitiger Gabe von Furosemid oder Etacryns?ure. Eosinophilie, Arthralgie, Fieber, Exanthem, neuromuskul?re Blockade

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Yuval Shaked,Paul Nathan,Laura G. M. Daenen,Robert S. KerbelBei überwiegend renal ausgeschiedenen Substanzen kommt es im Falle einer Niereninsuffizienz zur Kumulierung des Antibiotikums. Die Dosis mu? der Schwere der Niereninsuffizienz (Kreatininclearance!) angepa?t werden. Die Gefahr der Nebenwirkungen ist abh?ngig vom Ausma? der Kumulation und der Toxizit?t der Substanz.

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