Titlebook: Understanding the Gut-Bone Signaling Axis; Mechanisms and Thera Laura R. McCabe,Narayanan Parameswaran Book 2017 The Editor(s) (if applicab

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Gut Microbiota and Bone Healthc microbes in the modulation of bone health. Finally, we propose an emerging field of the gut-brain-bone axis, in which the gut drives bone physiology via regulation of key hormones that are originally synthesized in the brain.

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Intestinal Regulation of Calcium: Vitamin D and Bone Physiologyrom studies in vitamin D receptor (VDR) null mice which showed that rickets and osteomalacia were prevented when VDR null mice were fed a rescue diet that included high calcium, indicating that the skeletal abnormalities of the VDR null mice are primarily the result of impaired intestinal calcium ab

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Intestinal Incretins and the Regulation of Bone PhysiologyLP-1), and glucagon-like peptide-2 (GLP-2) have also been found to play an important role in the regulation of bone turnover. These “incretin” hormones promote bone anabolism by stimulating osteoblast differentiation as well as increasing osteoblast longevity. In addition, GIP and perhaps GLP-2 atte

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Stomach and Boneintertwined regulation of gastric acid secretion and bone metabolism in regard of diseases caused by dysfunction of any of these or intermediary organs or mediators. The importance of the functions of the endocrine modulators 1,25(OH). vitamin D (calcitriol), PTH, and calcitonin becomes clear when s