| 書目名稱 | Transcriptional Control of Cell Growth | | 副標(biāo)題 | The E2F Gene Family | | 編輯 | Peggy J. Farnham (Associate Professor of Oncology) | | 視頻video | http://file.papertrans.cn/929/928111/928111.mp4 | | 叢書名稱 | Current Topics in Microbiology and Immunology | | 圖書封面 |  | | 描述 | It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through- out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state. Alterations in the mechanisms that nor- mally control this decision can lead to cancer, cell death, or loss of differentiated cellular phenotypes. The identification of the E2F gene family of transcription factors has allowed a more complete understanding of how the cell maintains an appropri- ate proliferative state. This volume provides an up-to-date ac- count of present reports concerning E2F as well as a framework for future investigations. E2F activity requires heterodimerization of two partners. Either partner can be one of several different transcription factors; E2Fl, E2F2, E2F3, E2F4, or E2F5 can heterodimerize with either DPl or DP2. Cellular promoters whose E2F sites mediate a link between transcription | | 出版日期 | Book 1996 | | 關(guān)鍵詞 | DNA; cell; cell cycle; cell nucleus; gene; gene regulation; growth; influence; protein; protein structure; pro | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-79910-5 | | isbn_softcover | 978-3-642-79912-9 | | isbn_ebook | 978-3-642-79910-5Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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