Titlebook: Topics and Perspectives in Adenosine Research; Proceedings of the 3 Eckehart Gerlach,Bernhard Friedrich Becker Conference proceedings 1987L

遺留之物

Structural Studies on Adenosine Ri Receptors from Rat Cerebral Cortexted a stable R.-N. complex..The functional size of the adenosine receptor in membranes was measured by radiation inactivation analysis. The high-affinity form of the receptor decayed linearly as a function of radiation dose and yielded a target size of 63 000 daltons.

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Kinetics of Endothelial Cell Ectonucleotidasesymes seem to be present in human umbilical vein endothelial cells although their relative activities are different. In contrast, cells cultured from human omental fat microvessels lack significant ecto-ATPase activity, although both these cell types and pig aortic endothelial cells possess ecto-[nucleoside diphosphate kinase].

Anticoagulants

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修正案

Cardiac Myocyte and Coronary Endothelial Cell Adenosine Transportese properties of endothelial cell adenosine transport probably limit the amount of vascular adenosine which reaches smooth muscle cells and serve to reduce myocyte-derived adenosine diffusion into the vascular space.

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征兵

Drug Interactions with Nucleoside Transport Systemsfor the transporter..Quantitative assessments of drug interactions with nucleoside transport systems, either by direct flux studies or by correctly validated high-affinity binding probes, will extend our knowledge of transporter subtypes and the symmetry of transporters with respect to substrates and inhibitors.

airborne

New Insights into the Mechanism of Myocardial Adenosine Formationeased from cardiomyocytes, subsequently dephosphorylated by endothelial ecto-5′-nucleotidase, and further degraded by intracellular enzymes of the coronary endothelium. Similar processes may occur in vivo only under severely pathophysiological conditions.

gregarious

Analogues of Adenosine, Theophylline, and Caffeine: Selective Interactions with A1 and A2 Adenosine Receptors. Certain analogues of caffeine in which the methyl group at the 1- or 7-position is replaced with a propargyl or propyl group display selectivity for A. receptors. The profile of a series of adenosine analogues or of xanthine antagonists can be used to define the class of adenosine receptors.

Fatten

Uric Acid, the Major Catabolite of Cardiac Adenine Nucleotides and Adenosine, Originates in the Coronary Endotheliumcleotide catabolism arises by virtue of the activity of the microvascular endothelial marker enzyme xanthine dehydrogenase/oxidase. The irreversible reaction to uric acid makes the endothelium to a metabolic sink for myocyte-derived adenosine.