| 書目名稱 | The Prostaglandins | | 編輯 | Peter W. Ramwell | | 視頻video | http://file.papertrans.cn/918/917859/917859.mp4 | | 圖書封面 |  | | 描述 | There is much evidence to suggest that prostaglandins may have a physiological role to play in the control of thyroid gland metabolism, although the precise nature of this role remains to be defined. Prostaglandins have been found in normal thyroid tissue, and there is evidence of increased levels in some, but not all, cases of medullary carcinoma of the thyroid. which may account for the associated diarrhea. Exogenous prostaglandins, like TSH, bind to thyroid plasma mem- branes, stimulate the adenylate cyclase-cyclic AMP system, thyroid hormone secretion, iodide organification, colloid droplet formation, glucose oxidation, and 32p incorporation into phospholipids. Prosta- glandins of the E series are the most potent, although their maximal effects are generally less than the maximal effects of TSH. The interrelationships existing between TSH and prostaglandins have been the subject of intensive investigation, but as yet no one uni- fying concept has emerged. TSH and prostaglandins have been shown to occupy different receptors on the thyroid plasma membrane. Al- though TSH can increase intracellular prostaglandin levels, probably as a result of increased synthesis, prostaglandins d | | 出版日期 | Book 1974 | | 關(guān)鍵詞 | ATP; Coenzym; Nucleotide; Oxidation; enzyme; enzymes; metabolism; pharmacology; receptor; synthesis | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4613-4544-2 | | isbn_softcover | 978-1-4613-4546-6 | | isbn_ebook | 978-1-4613-4544-2 | | copyright | Plenum Press, New York 1974 |
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