Titlebook: Sepsis and Organ Dysfunction; The Challenge Contin A. E. Baue,G. Berlot,J.-L. Vincent Conference proceedings 2000 Springer-Verlag Italia 20

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Mechanism of Oxygen Extraction Defect in Septic Shockents cardiac output may increase to values above 15 lxmin. and mixed venous oxygen saturation may exceed normal values demonstrating decreased systemic oxygen extraction. Despite high systemic blood flow, progressive lactic acidosis and irreversible shock develops, suggesting progressive deteriorati

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The Kidney in Sepsiss 15% of patients with critical illness [1] and sepsis appears to be a contributing factor in as many as 43 %[2] . In addition, the kidney is usually the organ that fails first [3]. While the mortality rate of isolated acute renal failure is approximately 10 to 15%, ARF in the setting of sepsis carr

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Pathophysiology of Liver Dysfunction in Sepsis tests. Severe liver dysfunction is reported to occur in 12–95% of adult respiratory distress syndrome patients and liver blood tests on the first day of diagnosis are predictive of survival [1]. Liver failure is a critical determinant of mortality in trauma [2], in intra-abdominal sepsis [2], and a

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Inflammatory Cells in Septic Shockonses, which can lead to multiple organ failure and the suppression of immune responses. The effector cells play a pivotal role in the pathogenesis of this complex condition. For example, macrophages are a principal source of the key mediators of septic shock that produce pro-inflammatory cytokines

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Are There Useful New Markers of Sepsis?ion such as changes in body temperature, leukocytosis, and tachycardia are frequently used for the diagnosis of infection or sepsis [1]. However, these signs and symptoms are neither specific nor sensitive for infection or sepsis. Various other and non-microbial infection related aetiologies of syst

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