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Titlebook: Reviews of Physiology, Biochemistry and Pharmacology 156; S.G. Amara,E. Bamberg,M. Schweiger Book 2006 The Editor(s) (if applicable) and T

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書(shū)目名稱(chēng)Reviews of Physiology, Biochemistry and Pharmacology 156
編輯S.G. Amara,E. Bamberg,M. Schweiger
視頻videohttp://file.papertrans.cn/830/829652/829652.mp4
叢書(shū)名稱(chēng)Reviews of Physiology, Biochemistry and Pharmacology
圖書(shū)封面Titlebook: Reviews of Physiology, Biochemistry and Pharmacology 156; S.G. Amara,E. Bamberg,M. Schweiger Book 2006 The Editor(s) (if applicable) and T
描述Gastric acid plays a primary role in digestion as well as in the sterilization of food and water. Gastric juice contains the most concentrated physiological acid solution (pH~1) as a result + – of H and Cl ion secretion [hydrochloric acid (HCl) production] by parietal cells in the oxyntic mucosa of the stomach. The combined output of the parietal cells leads to the sec- tion of 1–2 l of HCl at a concentration of 150–160 mmol/l into the interior of the stomach. In order to facilitate the production of acid, the parietal cell relies on the generation of a high + concentration of H ions that are transported into the lumen of the gland. This process is fa- + + cilitated by activation of the gastric H ,K -ATPase, which translocates to the apical pole of + – the parietal cell. K as well as ATP hydrolysis and Cl all play critical roles in the activation + + of gastric H ,K -ATPase and are essential for the functioning of the enzyme (Reenstra and Forte 1990). This review will examine the classical proteins that have been linked to acid secretion as well as some recently identi?ed proteins that may modulate gastric acid secretion, in - dition we discuss the known secretagogues, and their re
出版日期Book 2006
關(guān)鍵詞H,KATPase; J-protein; RNA polymerase II; TRP channels cation channels; cells; gastric gland; lead; molecula
版次1
doihttps://doi.org/10.1007/978-3-540-33146-9
isbn_softcover978-3-642-06824-9
isbn_ebook978-3-540-33146-9Series ISSN 0303-4240 Series E-ISSN 1617-5786
issn_series 0303-4240
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
The information of publication is updating

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Role of the Mediator complex in nuclear hormone receptor signaling,ex functions by serving as a?molecular bridge between DNA-bound transcriptional activators and the basal transcription apparatus. In humans, Mediator was first characterized as a?thyroid hormone receptor (TR)-associated protein (TRAP) complex that facilitates ligand-dependent transcriptional activat
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An update on acid secretion,pical surface of the parietal cell. Activation of any or all these pathways causes the parietal cell to secrete concentrated acid with a?pH at or close to 1. This acidic fluid combines with enzymes that are secreted from neighbouring chief cells and passes out of the gland up through a?mucous gel la
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0303-4240 ed physiological acid solution (pH~1) as a result + – of H and Cl ion secretion [hydrochloric acid (HCl) production] by parietal cells in the oxyntic mucosa of the stomach. The combined output of the parietal cells leads to the sec- tion of 1–2 l of HCl at a concentration of 150–160 mmol/l into the
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978-3-642-06824-9The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
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