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Titlebook: Reverse Transcriptase Inhibitors in HIV/AIDS Therapy; Vassil St.Georgiev,Gail Skowron (Chief),Joep M. A. Book 2006 Humana Press 2006 AIDS.

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發(fā)表于 2025-3-21 16:06:25 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Reverse Transcriptase Inhibitors in HIV/AIDS Therapy
編輯Vassil St.Georgiev,Gail Skowron (Chief),Joep M. A.
視頻videohttp://file.papertrans.cn/830/829407/829407.mp4
概述Includes supplementary material:
叢書名稱Infectious Disease
圖書封面Titlebook: Reverse Transcriptase Inhibitors in HIV/AIDS Therapy;  Vassil St.Georgiev,Gail Skowron (Chief),Joep M. A. Book 2006 Humana Press 2006 AIDS.
描述A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.
出版日期Book 2006
關鍵詞AIDS; HIV; HIV/AIDS; drug; drug discovery; drug resistance; kinetics; pharmacokinetics; pharmacology; prevent
版次1
doihttps://doi.org/10.1007/978-1-59745-085-0
isbn_softcover978-1-61737-695-5
isbn_ebook978-1-59745-085-0
copyrightHumana Press 2006
The information of publication is updating

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Zidovudine, Lamivudine, and Abacavir,ot only because it was the first Food and Drug Administration (FDA)-approved agent for the treatment of HIV, but for the unprecedented speed with which this drug moved through the new-drug approval process (Table 1). In March 1987, ZDV was approved by the FDA for use in HIV-infected individuals with
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Stavudine, Didanosine, and Zalcitabine,nd in 1987, researchers logically turned to other nucleoside analogs in an attempt to expand the armamentarium against the disease. The next three compounds in this class to become commercially available were didanosine (as Videx?, Bristol Myers Squibb) in 1991, zalcitabine (as Hivid?, F. Hoffmann-L
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Emtricitabine,ering only in having a fluoride at the 5-position of the cytosine ring. Emtricitabine is the (& minus) enantiomer, which is more active than the (+) enantiomer. Emtricitabine has a long plasma half-life (10 h), and even longer intracellular half-life of the active triphosphate (39 h), supporting onc
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