Titlebook: Regulatory Toxicology; Franz-Xaver Reichl,Michael Schwenk Living reference work 20200th edition

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Integration of Advanced Technologies into Regulatory Toxicology,pproach for specific endpoints. The Tox21 concept, which is relying on advanced technologies, using human stem cells, multiorgan-chips and in silico models will most probably prove that the future of toxicology will be in vitro.

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International Regulation of Toxicological Test Procedures, accept new nonanimal tests only, if they allow to classify and label chemicals in the same way as the animal tests. The OECD has, therefore, decided to accept new in vitro toxicity tests, for example, for cosmetics, for regulatory purposes only after successful experimental validation. Therefore, i

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Characterization of Physicochemical Parameters in Toxicology,are known. These properties determine to a large extent the behavior of a substance in the environment and in the living organism. Thus, knowledge of physicochemical properties is important for the development of therapeutic drugs as well as for the risk assessment of all chemicals.

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Specific Toxicity Tests for Neurotoxicity, Immunotoxicity, Allergy, Irritation, Reprotoxicity, and o other test methods such as testing for possible immunotoxic or neurotoxic properties of a substance. Special, usually internationally applicable, test guidelines form the regulatory basis for the test methods, which apply to chemicals, crop protection products, and medicinal products.