Titlebook: Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research; Helmut Sinzinger,Bengt Samuelsson,Patrick Y.-K. Wo Book 1997 The

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Mitogen-Activated Protein Kinases and Endothelial Prostacyclin Secretion,othelial cells, is a potent vasorelaxant and inhibitor of platelet aggregation (1). As with other eicosanoids, PGI. is biosynthesized from free arachidonic acid (AA) released from membrane phospholipids, primarily through the enzymatic action of cytosolic phospholipase A. (cPLA.) (1, 2). It has been

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Crosstalk Between Elevation of [Ca2+]i, Reactive Oxygen Species Generation and Phospholipase A2 Stior role that [Ca.]i may play in these processes in the human keratinocyte cell line, HaCaT. HaCaT cells can be invoked to transiently produce ROS by epidermal growth factor (EGF), thapsigargin (TPG) and the Ca.-ionophore, A23187. These 3 agonists transiently increase [Ca.]i with characteristic kinet

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Biosynthesis of Novel Divinyl Ether Oxylipins by Enzyme From Garlic (, L.) Bulbs,se oxylipins, is controlled by 9-lipoxygenase activity and an enzyme, controlling dehydration of 9-hydroperoxide. Such a pathway, being not found in any other plant or animal species, was considered to be the unique property of potato tubers. Our recent . studies of lipoxygenase pathway in garlic bu

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Catalytic and Spectroscopic Properties of Linoleate Diol Synthase of the Fungus ,,nt for sporulation. The fungus can sequentially metabolize linoleic acid (18: 2n-6) to 8R-hydroperoxylinoleic acid (8-HPODE) through an 8-dioxvgenase and to 7S,8S-dihydroxylinoleic acid (7,8-DiHODE) through a hydroperoxide isomerase.. A highly purified protein with both enzyme activities was recentl

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