Titlebook: RUNX Proteins in Development and Cancer; Yoram Groner,Yoshiaki Ito,Andre van Wijnen Book 2017 This is a U.S. Government work and not under

HALL

Roles of the , Enhancer in Normal Hematopoiesis and Leukemogenesisty of enhancers is tightly regulated in an integrated and combinatorial manner, thus yielding complex patterns of transcription in different tissues. Identifying enhancers is crucial to understanding the physiological and pathogenic roles of their target genes. The . intronic enhancer, eR1, acts in

Observe

RUNX1-ETO Leukemiachieved in understanding the molecular pathogenesis of AML1-ETO leukemia. Proteomic surveies have shown that AML-ETO forms a stable complex with several transcription factors, including E proteins. Genome-wide transcriptome and ChIP-seq analyses have revealed the genes directly regulated by AML1-ETO

Femish

放逐某人

Mechanism of ETV6-RUNX1 Leukemiahe fusion of the . and . genes. Since its discovery in the 1990s, the function of the . fusion gene has attracted intense interest. In this chapter, we will summarize current knowledge on the clinical significance of ., the experimental models used to unravel its function in leukemogenesis, the iden

dysphagia

沐浴

Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemiaand maintenance. The inv(16)(p13q22) rearrangement is a founding mutation and the associated CBFβ-SMMHC fusion protein is essential for the survival of inv(16) AML cells. This Chapter will discuss our understanding of the function of this fusion protein in disrupting hematopoietic homeostasis and cr

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FICE

Mechanism of ETV6-RUNX1 Leukemiatification of co-operating mutations and the mechanisms responsible for their acquisition, the function of the encoded transcription factor and finally, the future therapeutic approaches available to mitigate the associated disease.

喪失

Roles of the , Enhancer in Normal Hematopoiesis and Leukemogenesisr of enhancers termed a super-enhancer. The . super-enhancer is observed in normal HSCs and T-cell acute lymphoblastic leukemia cells. In this review, we describe the discovery of eR1 and its roles in normal development and leukemogenesis, as well as its potential applications in stem cell research.