Titlebook: RNA Therapeutics; Amanda L. Garner Book 2018 Springer International Publishing AG 2018 microRNAs.therapeutic approach.G-quadruplexes.viral

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Viral RNA Targets and Their Small Molecule Ligands,avirus (SARS CoV), influenza A, and insect-borne flaviviruses (Dengue, Zika, and West Nile) as well as filoviruses (Ebola and Marburg). Here, I will review recent progress on the discovery and design of small molecule ligands targeting structured viral RNA motifs.

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cell type. The commercial electroporation systems have been widely adopted in research and clinics with protocols usually compromising appropriate transfection efficiency and cell viability. By introducing gold nanoparticles (AuNPs), we demonstrated greatly enhanced performance of electroporation f

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Matthew G. Costales,Jessica L. Childs-Disney,Matthew D. Disneyon enables optimization of delivery efficiency by tuning the electric field applied on cells. Commercial electroporation, however, results in stochastic transfection and significant cellular damage mostly due to its “bulk” environment. In this chapter, we introduce nanoelectroporation (NEP) which ha

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Avalanche Transistor-Based Nanosecond Pulse Generator,rcuit-based pulse generator is designed using avalanche transistors (AT) and experimentally validated. Each stage consists of 13 numbers ATs in series. Disk ceramic capacitors charge up to supply voltage through the isolating resistors. To achieve fast rise time, the loop inductance was minimized th