Titlebook: RNA Metabolism in Neurodegenerative Diseases; Rita Sattler,Christopher J. Donnelly Book 2018 Springer International Publishing AG, part of

大都市

Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes, have been implicated in the regulation of . exon 7 splicing. There is evidence to support that multiple exons of . are alternatively spliced during oxidative stress, which is associated with a growing number of pathological conditions. Here, we provide the most up to date account of the mechanism of splicing regulation of the . genes.

indicate

RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases,ation and aggregation of the nucleoporins that make up the nuclear pore; alterations in the Ran gradient and the proteins that control it which impacts exportin based nuclear export; and alterations of proteins that are required for the export of mRNA leading nuclear accumulation of mRNA.

輕信

種植,培養(yǎng)

600

immunity

Stress Granules and ALS: A Case of Causation or Correlation?, summarize current understanding of stress granules, focusing on assembly and clearance. We also assess the evidence linking alterations in stress granule formation and dynamics to ALS protein aggregates and disease pathology.

CRAB

foreign

向宇宙

RNP Assembly Defects in Spinal Muscular Atrophy, important role in an extensive and diverse set of cellular processes that regulate neuronal growth, differentiation, and the maturation and plasticity of synapses. This review discusses the role of SMN in RNP assembly and localization, focusing on molecular defects that affect mRNA processing and may contribute to SMA pathology.

維持