| 書目名稱 | Protein Misfolding and Disease |
| 編輯 | Peter Bross,Niels Gregersen |
| 視頻video | http://file.papertrans.cn/762/761711/761711.mp4 |
| 概述 | Includes supplementary material: |
| 叢書名稱 | Methods in Molecular Biology |
| 圖書封面 |  |
| 描述 | For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which mutations or environmental stresses may result in a partial misfolding that leads then to alternative conformations capable of disturbing cellular processes. This may happen by self-association (aggregation), as in prion and Alzheimer’s diseases, or by incorporation of alternatively folded subunits into structural entities, as in collagen diseases. Another possibility is that folding to the native structure is impaired or abolished, resulting in decreased stea- state levels of the correctly fold |
| 出版日期 | Book 2003 |
| 版次 | 1 |
| doi | https://doi.org/10.1385/1592593941 |
| isbn_softcover | 978-1-61737-332-9 |
| isbn_ebook | 978-1-59259-394-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 |
| issn_series | 1064-3745 |
| copyright | Humana Press 2003 |
|Archiver|手機版|小黑屋|
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