| 書目名稱 | Poly(ADP-ribose) Polymerase | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Alexei V. Tulin | | 視頻video | http://file.papertrans.cn/752/751050/751050.mp4 | | 概述 | Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes supplementary materia | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | .Poly (ADP-ribose) Polymerases (PARPs) are abundant and ubiquitous proteins that regulate crucial processes of the cell cycle, DNA repair, genomic stability, and transcriptional regulation.? Being involved in basic cell functions, PARPs mediate rapid responses to such environmental factors as stress, infection, nutrition and hormonal signals. Whereas PARP inhibitors can suppress tumor growth and proliferation in certain breast, ovarian, and prostate cancers, understanding how PARP controls cellular functions is essential for the development of novel cancer treatments strategies. Divided into three convenient sections, .Poly(ADP-Ribose) Polymerase: Methods and Protocols. aims to explain how PARP proteins act within the normal development of an organism as well as in pathogenic conditions, seeks to advance the knowledge of developmental pathways regulation, and endeavors to facilitate the development of new therapeutic drugs and methods to target PARP-dependent processes. Written in the highly successful .Methods in Molecular Biology?. series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reprodu | | 出版日期 | Book 2011 | | 關(guān)鍵詞 | PARP inhibitors; PARP1 genomics; drosophila; mammalian genome; mass spectrometry; non-covalent pADPr inte | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-61779-270-0 | | isbn_softcover | 978-1-4939-6215-0 | | isbn_ebook | 978-1-61779-270-0Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Springer Science+Business Media, LLC 2011 |
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