Titlebook: Opioid Receptors; Methods and Protocol Santi M. Spampinato Book 2015 Springer Science+Business Media New York 2015 Agonist ligands.Behavior

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Overview of Genetic Analysis of Human Opioid Receptorss. The μ-opioid receptor (MOR), encoded by OPRM1, contributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Genetic polymorphisms of opioid receptors are candidates for the variability of clinical

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Analysis of Epigenetic Mechanisms Regulating Opioid Receptor Gene Transcriptionpioid receptors are still invaluable because not only transcription is the first step to produce protein products in cells, but the receptor transcription levels also affect the pain reduction by opioids, as observed in studies of heterozygous opioid receptor knockout mice..There are growing evidenc

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Bioluminescence Resonance Energy Transfer (BRET) to Detect the Interactions Between Kappa Opioid Recpled receptors (GPCRs) hetero- and homo-dimerization. Recently, BRET has also been used to investigate the interaction between GPCRs (e.g., β. adrenergic receptor, muscarinic M2 receptor, dopaminergic D. receptor) and non-visual arrestins. Here a BRET protocol is described to investigate interaction

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