Titlebook: Nucleic Acids: The Vectors of Life; Proceedings of the S Bernard Pullman,Joshua Jortner Conference proceedings 1983 D. Reidel Publishing Co

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Dynamic Structure of Z-DNA,educed from the titration of form V DNA by the antibodies to Z-DNA. We then report some results on exchange kinetics of the protons involved in hydrogen bonds between base pairs of poly(dG-m.dC).poly(dG-m.dC), in Z conformation. There are two classes of protons, a fast one the exchange half-time of

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Relative Stability of B and Z Structures in Oligodeoxynucleotides with Different Alternating Base SD technique. Although the solution conditions should favor the Z-conformation, only C-G sequences are found in this structure. (G-C). sequences with n up to 5 do not assume the left-handed conformation. The concatamer obtained with d(AT).(CG). in high salt solution was found in B conformation wherea

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Electrostatic Molecular Potential Versus Field in Nucleic Acids and Their Constituents,bution in the nucleic acids and their constituents and are influenced differently by such environmental factors as counterion screening. They also govern the electrostatics of interaction of DNA with different types of species, the MEP being of particular significance in this respect for interaction

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,Probing for and with Left-Handed DNA: Poly[d(A-br5c)?d(G-T)], a Member of a New Family of Z-Formingbstitution at the pyrimidine C5 heterocyclic position. A representative polynucleotide is poly[d(A-br.C)?d(G-T)]. Elevation of salt concentration and temperature shifts the equilibrium in favor of the left-handed state. The spectral changes (u.v. absorption, c.d., NMR, Raman) accompanying the highly

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Structures of DNA: A Case Study of Right and Left Handed Duplex in the B-Form,f the six torsion angles of the backbone as possible for both right and left-handed helical duplexes for DNA. Out of these combinations, a total of five models, three right-handed and two left-handed double helices are seen to be compatible with X-ray data of B-DNA. A comparison of these models with

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Dependence of Oligonucleotide Conformational Properties on Sugar Ring and Base-Sequence. 1H and 13Cc recognition sites for protein or drug binding. Part of the interest stems from the fact that variations in DNA structure with base sequence have been observed; for example, the recent crystal structure of a DNA dodecamer by Dickerson and Drew (1981) showed several departures from the ideal, regula

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Conformational Flexibility of Nucleic Acids,spects of dynamics with molecular Mechanics calculations providing supplementary insight. Analysis of .P and .C NMR relaxation data in terms of plausible motions in a DNA helix indicate that winding and unwinding, base tilting and base pair propelling are not viable, but sugar repuckering and other