Titlebook: Nucleic Acids and Molecular Biology; Fritz Eckstein,David M. J. Lilley Book 1988 Springer-Verlag Berlin Heidelberg 1988 DNA.DNA repair.Nuc

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Laser Raman Spectroscopy of Nucleic Acids,l details of right- and left-handed DNA helices at atomic resolution. [For comprehensive reviews of this work, see the monograph edited by Jurnak and McPherson (Jurnak and McPherson 1985).] Structural details of DNA in complexes with regulatory proteins (Anderson et al. 1987) and anti-tumor drugs (W

Wernickes-area

Non-Commensurate Polypurine/Polypyrimidine DNA Structures, solution. The torsion associated with the underwinding represents a considerable store of conformational energy which can be expressed in a variety of ways. Perhaps the most interesting of these is its ability to cause structural transitions in segments of DNA which are unusual in either base compo

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Sequence Specific Recognition of Double Helical DNA. A Synthetic Approach,ing and affinity cleaving which allow rapid and precise analyses of hundreds of potential DNA-binding sites to nucleotide resolution on sequencing gels (Dervan 1986). During the past 10 years our group has focused on the construction of molecules that bind in the minor and major groove of DNA with i

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Metal Complexes Which Target DNA Sites: Coupling Recognition to Reactivity,city required by DNA-binding proteins and enzymes, which are able to bind a specific small sequence of bases, in the presence of the remaining genomic sequences, and having found the site of interest, carry out a complex series of reactions there. We would like to understand some of the rules which

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,Oligo-[α]-Deoxyribonucleotides Covalently Linked to Intercalating Agents. A New Family of Sequence-985; Green et al. 1986). An oligonucleotide can be targeted to a messenger RNA. Complex formation via hydrogen bonding interactions (base pair formation) is expected to interfere with mRNA processing or translation and consequently inhibits protein synthesis. When targeted to a viral RNA the oligonu

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Protein-Induced DNA Bending,tion of DNA. In these structures the DNA follows a defined three-dimensional path — or configuration. However, the DNA double helix does not behave as an isotropic rod. Instead, the structural and mechanical properties of DNA vary in a sequence-dependent manner resulting in a molecule which is flexu

dowagers-hump

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NMR Studies of Repressor-Operator Interaction. The , Control Region,me clues have come from the well-known crystallographic studies on . (Anderson et al. 1981) and . repressors (Pabo and Lewis 1982), CAP (McKay and Steitz 1981) and, more recently, . repressor (Schevitz et al. 1985). All these proteins have a very similar helix-turn-helix structural domain, which is