Titlebook: Neurotoxic Factors in Parkinson’s Disease and Related Disorders; Alexander Storch,Michael A. Collins Book 2000 Springer Science+Business M

PLE

Role of Microtubules in the Genesis of MPTP Neurotoxicityise pattern of cytoskeleton reorganisation and its possible role in their formation and in evoking neurodegeneration remains speculative. To elucidate some aspects of this crucial point the neurotoxin MPTP, l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine, may represent a useful tool.

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護(hù)身符

Endogenous Brain Catechol Thioethers in Dopaminergic Neurodegenerationt manner from 5 to 50 .M. The apoptotic effect of dopamine was greatly enhanced by subcytotoxic concentrations of he mitochondrial inhibitor, .-methyl-4-phenylpyridinium (MPP.). Similarly, subcytotoxic levels of the mercapturate or homocysteine conjugate of dopamine significantly augmented dopaminei

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Potential Roles of Accelerated Dopamine Oxidation, Altered Glutathione Metabolism, 5-S-Cysteinyl-Dop information derived from studies of the dopaminergic neurotoxicity of 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine and methamphetamine, a new pathological mechanism is proposed that might contribute to an understanding of SNpc cell death in PD. This neurotoxic mechanism is suggested to be initiated

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Neurotoxic Factors in Parkinson’s Disease and Related Disorders

漫步

Neurotoxic Factors in Parkinson’s Disease and Related Disorders978-1-4615-1269-1

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