Titlebook: Neuroinflammation and Neurodegeneration; Phillip K. Peterson,Michal Toborek Book 2014 Springer Science+Business Media New York 2014 Alzhei

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G. von Geldern M.D.,M. J. Barhams M.H.S.A.,E. O. Major Ph.D.

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The Blood-Brain Barriertranscellular exchange of substances across the endothelium. The physiological properties of endothelial cells, however, are regulated by their interaction with astrocytes and pericytes that in turn interact with each other and nearby neurons. This chapter explores the cellular structure of the bloo

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Immune Cell Trafficking in the Central Nervous System autoimmune disease, the immune system appears to be involved in many neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease. Thus, the factors that support lymphocyte entry and function in various settings of neuroinflammation are of great interest. In the following chapte

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Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson’s Diseaseing and presentation of modified proteins, such as nitrated ?-synuclein by dendritic cells, induce effector T cells to those nitrated epitopes that act as neoantigens. Robust effector T cell immune responses against nitrated or modified self-proteins and migration of those effector T cells to inflam

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Neuroinflammation in Huntington’s Diseases to conduct clinical studies and learn about early events in the development of HD. One of the earliest pathological changes observed in the CNS of HD patients is the appearance of neuroinflammation, preceding overt neurodegeneration or protein aggregation. Here we will review the data implicating

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Neuroinflammation and Immune Regulation in Ischemic Stroke: Identification of New Pharmacological Ta ways, and better insight into these interactions may be relevant to the treatment of patients with stroke and other forms of central nervous system injury. However, during recent years, promising findings suggest that systemic inflammation and neuroinflammation are central features in cerebrovascul

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