Titlebook: Neuroinflammation; Mechanisms and Manag Paul L. Wood (Director) Book 19981st edition Springer Science+Business Media New York 1998 Alzheime

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The Role of Cell-Adhesion Molecules in Neurological Disorderswith two different approaches currently in use. In the first approach, attempts are being made to block the accumulation of leukocytes at the site of inflammation by targeting the various CAMs that are involved in leukocyte rolling, arrest, and trans-endothelial migration. Strategies in this area ar

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The Role of Glial Nitric Oxide in Neurotoxicity and Central Nervous System Diseasest these cells are not simply “packing material” for neurons, but serve in many important capacities. Glia facilitate neuronal migration during development, assist in the maintenance of the neuronal milieu for normal neurotransmission, produce neurotrophic factors, participate in immunological respon

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Microgliosis and Impaired Cognition-1) or clustered about senile plaques found in Alzheimer’s disease (AD) (Fig. 1; refs. . and .). We propose that chronic reactive microgliosis destroys neurons and contributes to loss of cognitive function. Blockade of activated microglia may slow cognitive deterioration occurring with inflammatory dementia.

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Book 19981st edition potential clinical relevance to AIDS-related dementia, Alzheimer‘s disease, amyotropic lateral sclerosis (ALS), Down‘s syndrome, Huntington‘s disease, multiple sclerosis, Parkinson‘s disease, and stroke.

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ell as the potential clinical relevance to AIDS-related dementia, Alzheimer‘s disease, amyotropic lateral sclerosis (ALS), Down‘s syndrome, Huntington‘s disease, multiple sclerosis, Parkinson‘s disease, and stroke.978-1-59259-473-3