Titlebook: Nasopharyngeal Carcinoma; Keys for Translation Pierre Busson Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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Acquired Genetic and Epigenetic Alterations in Nasopharyngeal Carcinoma,ar investigations and bioinformatics have disclosed critical genetic and epigenetic events in NPC. In this chapter, we will focus on important genetic and epigenetic alterations in NPC derived from EBV positive NPC cell lines and human tumoral tissues. Copy number losses on chromosomes 1p, 3p, 9p, 9

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Biological Tools for NPC Population Screening and Disease Monitoring,ggressiveness and rapid assessment of treatment efficacy. Because of the selective infection of the malignant NPC cells by the Epstein-Barr virus, most of the research on tumor biomarkers and other biological tools for NPC screening and monitoring has been oriented towards detection of antibodies ag

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The Evolving Role of Systemic Therapy in Nasopharyngeal Carcinoma: Current Strategies and Perspectiradiotherapy, improvement in tumor imaging and disease monitoring, and advances in high precision radiotherapy delivery. Several randomized trials have established concurrent chemoradiation (with or without adjuvant chemotherapy) as the standard of care in advanced NPC. Current efforts are building

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Nasopharyngeal Carcinoma Immunotherapy: Current Strategies and Perspectives,mmunotherapy has led to interest in the development of CTL-based immunotherapy to treat other EBV-associated malignancies, including Nasopharyngeal carcinoma (NPC). However unlike PTLD, which arises in immunosuppressed individuals following transplant, NPC can arise in immunocompetent individuals, e

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Therapeutic Induction of Apoptosis in Nasopharyngeal Carcinoma,rendering cells resistant to apoptosis are acquired in virtually all cancers. A full understanding of such mutations is important for the development of clinically successful therapeutic strategies..In nasopharyngeal carcinoma (NPC), inhibition of both receptor- and mitochondrial-mediated apoptosis

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