| 書目名稱 | Molecular Dynamics Analyses of Prion Protein Structures | | 副標(biāo)題 | The Resistance to Pr | | 編輯 | Jiapu Zhang | | 視頻video | http://file.papertrans.cn/639/638200/638200.mp4 | | 概述 | Systemically studies all the structures of PrPs and associations.Introduces the reproducible Molecular Dynamics, QM/MM, Optimization skills into the studies.The 1011 color photos lead you are fast and | | 叢書名稱 | Focus on Structural Biology | | 圖書封面 |  | | 描述 | .Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrP.C.) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book..Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Str?ussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutan | | 出版日期 | Book 2018 | | 關(guān)鍵詞 | Prion Protein Structure; Molecular Dynamics Simulation; Structural Dynamics; Molecular Structure; Prion | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-10-8815-5 | | isbn_softcover | 978-981-13-4247-9 | | isbn_ebook | 978-981-10-8815-5Series ISSN 1571-4853 Series E-ISSN 2542-9566 | | issn_series | 1571-4853 | | copyright | Springer Nature Singapore Pte Ltd. 2018 |
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