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Titlebook: Microdomains in the Cardiovascular System; Viacheslav Nikolaev,Manuela Zaccolo Book 2017 Springer International Publishing AG 2017 microdo

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發(fā)表于 2025-3-21 18:10:49 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Microdomains in the Cardiovascular System
編輯Viacheslav Nikolaev,Manuela Zaccolo
視頻videohttp://file.papertrans.cn/634/633176/633176.mp4
概述First book comprehensively reviewing signaling microdomains in the cardiovascular system.Thoroughly explains important cellular events and mechanisms.Highlights the role of microdomains in cardiovascu
叢書(shū)名稱Cardiac and Vascular Biology
圖書(shū)封面Titlebook: Microdomains in the Cardiovascular System; Viacheslav Nikolaev,Manuela Zaccolo Book 2017 Springer International Publishing AG 2017 microdo
描述The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future..This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.?.
出版日期Book 2017
關(guān)鍵詞microdomain; signaling; cardiovascular; cardiomyocyte; second messenger
版次1
doihttps://doi.org/10.1007/978-3-319-54579-0
isbn_softcover978-3-319-85430-4
isbn_ebook978-3-319-54579-0Series ISSN 2509-7830 Series E-ISSN 2509-7849
issn_series 2509-7830
copyrightSpringer International Publishing AG 2017
The information of publication is updating

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Viacheslav Nikolaev,Manuela ZaccoloFirst book comprehensively reviewing signaling microdomains in the cardiovascular system.Thoroughly explains important cellular events and mechanisms.Highlights the role of microdomains in cardiovascu
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Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytesnt subcellular locations. Caveolae, which represent a specific subset of lipid rafts, can dynamically attract or exclude specific signaling proteins through a variety of mechanisms to create highly localized and self-sufficient multi-molecular signaling complexes. Furthermore, disruption of this org
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Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Hearty hypertension. However, these drugs do not seem efficient in heart failure with preserved ejection fraction. There is experimental evidence that these PDEs as well as other PDE families including PDE1, PDE2 and PDE9 may play important roles in cardiac diseases such as hypertrophy and heart failure.
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cAMP Compartmentalisation and Hypertrophy of the Heart: ‘Good’ Pools of cAMP and ‘Bad’ Pools of cAMPsiology and pathophysiology. In this chapter, we review some of the evidence in support of compartmentalisation of cAMP/PKA signalling, and we summarise recent findings indicating that distinct pools of cAMP, under the control of different phosphodiesterases, have opposing effects on cardiac myocyte
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