Titlebook: Metastasis of Prostate Cancer; Richard J. Ablin,Malcolm D. Mason Book 2007 Springer Science+Business Media B.V. 2007 bisphosphonates.cell.

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Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity,d vasculogenic mimicry, resulting in acquisition of the metastatic phenotype. A better understanding of the molecular mechanisms underlying prostate tumor cell plasticity may provide new prognostic markers for clinical diagnosis and novel therapeutic intervention strategies for disease management.

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Strategies for the Implementation of Chemotherapy and Radiotherapy,roved symptom control, to a discussion on novel agents currenthy under investigation..The role of ionising radiation therapy, both external beam radio therapy and bone - seeking radio nuclide therapy, in the palliation of disease related symptom particularly bone pain is also discussed.

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Orthotopic Metastatic Mouse Models of Prostate Cancer,f prostate cancer. The use of green Cancer statistics, luorescent protein and red fluorescent protein to image primary tumor growth and metastasis, including whole-body imaging of prostate cancer, is discussed. The application of the models for gene expression studies, drug discovery, and gene therapy is also reviewed.

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,β-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer,f the Wnt signal transduction pathway. This chapter summarises some of the scientific and clinical advances made during the last decade on the molecular and cellular functions of β-catenin, including its role in Wnt signalling, adherence junction assembly and its impact on prostate cancer progression.

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