Titlebook: Metabolism and Functions of Bioactive Ether Lipids in the Brain; Akhlaq A. Farooqui,Tahira Farooqui,Lloyd A. Horroc Book 2008 Springer-Ver

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Degradation of Platelet-Activating Factor in Brain, lyso-PAF, which is biologically inactive (Fig. 8.1). The lyso-PAF can be reacylated by an acyl-CoA/1-radyl-.-glycero-3-phosphocholine acyltransferase. Alkyl-PAF is less potent than PAF. The alkyl moiety of lyso-PAF is degraded to an aldehyde by a tetrahydropiridine-dependent alkyl monooxygenase (Le

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Roles of Platelet-Activating Factor in Brain, and spinal cord trauma and ischemia trigger neuronal cell death (Bazan et al., 1997; Kornecki et al., 1996). In brain tissue, PAF may be associated with neural cell migration, gene expression, calcium mobilization, noniception, and long-term potentiation (Fig. 9.1). PAF interacts with neural and no

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Biochemical Effects of Nonphysiological Antitumor Ether Lipids,e 1-methoxy-2-.-methyl-octadecylamino-propyloxyphosphorylcholine (BN 52205), 1-methoxy-3-.-methyl-octadecylamino-propyloxyphosphorylcholine (BN 52207), 1-.-methyl-octadecylamino-2-methoxy-propyloxyphosphorylcholine (BN 52211) (Fig. 11.2). Besides the above-mentioned anticancer compounds, glycosidate

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Perspective and Directions for Future Developments on Ether Lipids,tidylethanolamine (PtdEtn), phosphatidylserine (PtdSer), and phosphatidylinositol (PtdIns), whereas ether bond containing glycerophospholipids include plasmalogens, platelet-activating factor (PAF) and its analogs (Farooqui and Horrocks, 2001). PtdCho is mainly located in the outer leaflet, whereas

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Book 2008ipase A2 and PAF acetyl hydrolase. This monograph will be first to provide a comprehensive description of not only metabolism and role of plasmalogen and platelet activating factor in brain tissue but also the involvement of these lipids with abnormal signal transduction processes in neurological disorders..

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Metabolism and Functions of Bioactive Ether Lipids in the Brain