Titlebook: Metabolic Changes Induced by Alcohol; G. A. Martini,Ch. Bode Book 1971 Springer-Verlag Berlin · Heidelberg 1971 cancer.central nervous sys

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978-3-540-05296-8Springer-Verlag Berlin · Heidelberg 1971

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Studies on the Inhibitory Effect on Ethanol Oxidation in Man After Administration of 4-Methylpyrazol understanding of the biochemical aspects of alcoholism. Recently BLOMSTRAND et al. (1,2) were able to establish distinct excretion patterns of .CO. in expired air in man after the administration of only 2 μC of ethanol-1-.C or ethanol-2-.C, thus enabling several consecutive studies with labelled ethanol to be made in human beings. (Fig. 1 and 2).

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Interaction between Ethanol Oxydation and Drug Metabolismo convert a wide variety of compounds into more polar (i.e., hydroxylated or dealkylated) derivatives. In our studies the increased oxygen uptake of perfused liver following the addition of a suitable substrate, e.g., aminopyrine, was used to estimate the rate of this microsomal process (1).

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The Development of Alcohol Dehydrogenase and its Isoenzymesre birth, due to its inhibitory effect on the release of oxytocin (LUUKKAINEN, V?IST?, and J?RVINEN, 1967). Since ethanol easily crosses the placental membranes and its oxidation has a marked effect on metabolic functions of the liver, we decided to study alcohol dehydrogenase (ADH) and alcohol oxid