Titlebook: Mechanisms of Gene Regulation; Carsten Carlberg,Ferdinand Molnár Textbook 20141st edition Springer Science+Business Media Dordrecht 2014 c

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Springer Science+Business Media Dordrecht 2014

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OVER

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CONE

https://doi.org/10.1007/978-94-007-7905-1chromatin; gene regulation; protein structure; signal transduction; transcription factors; gene expressio

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The Impact of Chromatingenome of 2?×?3.26?billion?bp, lines up to a length of some 2?m, i.e. 200,000 times the diameter of an average mammalian nucleus. Packing DNA inside the nucleus therefore imposes tremendous organizational challenges. The highly condensed packing of genomic DNA is achieved through i) wrapping it arou

MAZE

The Basal Transcriptional Machineryiption is controlled. Pol II is the core of the basal transcriptional machinery, which contains a large number of general transcription factors, many of them are summarized as the TFIID complex. Via another multi-protein complex of co-activators, termed Mediator, the basal transcriptional machinery

HAVOC

Transcription Factorsnmental pertubations. In humans there are approximately 1,900 site-specific DNA-binding transcription factors. The most characteristic domain of a transcription factor is its DBD, but they also contain domains for dimerization and for contacts with co-factors..Only a small subset of these 1,900 tran

Tremor

Linking Signal Transduction and Gene Regulationscades, which mostly start with an extracellular signaling molecule and end with an activated transcription factor. Latent transcription factors, such as SMAD, STAT, NFKB and others, are central to these pathways, as they are activated through different mechanisms of their translocation from the cyt

CRUE

Switching Genes on and off: The Example of Nuclear Receptorss in the size of cholesterol (approx.?400?Da). Some of these ligands are known as important endocrine hormones, such as estradiol and testosterone, while others are metabolites of dietary compounds, such as fatty acids and cholesterol. Both types of molecules are of large physiological impact in hea