Titlebook: Lipoxygenases in Inflammation; Dieter Steinhilber Book 2016 Springer International Publishing Switzerland 2016 allergic and cardiovascular

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Lipoxygenases in Inflammation978-3-319-27766-0Series ISSN 1422-7746 Series E-ISSN 2296-4525

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5-Lipoxygenase,des, and lipid hydroperoxides. 5-LO product synthesis in intact cells is modulated by phosphorylations at Ser271, Ser523, and Ser663, an elevated oxidative tone, and subcellular redistribution, apparently together with coactosin-like protein, from a soluble compartment to the nuclear membrane where it colocalizes with 5-LO-activating protein.

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The Physiology and Pathophysiology of Lipoxygenases in the Skin, a critical role of a distinct LOX pathway in the development and maintenance of the epidermal barrier. This review focuses on the activities and mechanisms of actions of individual LOX-derived oxylipins, and the dysregulation of the corresponding LOX enzymes in diseased skin.

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Book 2016so in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume sum

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Lipoxygenases: An Introduction,tions, the cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This . volume summarizes the physiological and pathophysiological functions of lipoxygenases.

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Leukotriene A4 Hydrolase and Leukotriene C4 Synthase,s, particularly in the respiratory tract and microcirculation. The committed steps in the biosynthesis of leukotriene B. and C. are catalyzed by the key enzymes . .. . and . .. ., respectively. In this chapter we discuss the most recent advances in the understanding of these two enzymes at a structural, functional, and biological level.