Titlebook: Irreversibility and Dissipation in Microscopic Systems; édgar Roldán Book 2014 Springer International Publishing Switzerland 2014 Brownian

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édgar Roldánase-deactivated Cas9 (dCas9) provide scientists with tools to modulate transcription of genomic loci at will by targeting transcriptional effector domains. To interrogate the temporal order of events during transcriptional regulation, rapidly inducible CRISPR/dCas9 systems provide previously unmet m

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édgar Roldánn a daily basis, which in turn calls for the development of powerful bioinformatics tools and efficient workflows to analyze them. One of the approaches to address the “big data” issue is to mine highly correlated clusters/networks of biological molecules, which may provide rich yet hidden informati

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édgar Roldánlity of core transcription machinery (Dvir et al. 2001, Sandelin 2007), the actions of promoter- or regulon-specific transcription factors (positive and negative) (e.g., (Malik and Roeder 2005, Hoffmann et al. 2006)), and the control of DNA accessibility by altering chromatin structure (Li et al. 20

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NA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only on

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édgar Roldángenetic influences are major causes of disease.The epigenome.Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the ar