Titlebook: Intrinsic Immunity; Bryan R. Cullen Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag

用手捏

Intractable

Inhibition of Retroviral Replication by Members of the TRIM Protein Family,ade restriction, suggesting that TRIM and viruses have coevolved for millions of years of primate evolution. Recently, TRIM5α returned to the limelight when it was shown to trigger the expression of antiviral genes upon recognition of an incoming virus, a paradigm shift that demonstrated that restri

鄙視讀作

Restriction of Retroviral Infection of Macrophages, of SAMHD1 is induced by Vpx to eliminate this intrinsic antiviral factor. Importantly, SAMHD1 has also been implicated as a negative regulator of the innate immune response, so the interplay between SAMHD1 and Vpx is likely to have significant consequences for virus replication, persistence, and im

Irremediable

Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors,extraordinary impact viruses have had on organismal evolution—an impact hitherto underappreciated by evolutionary biologists and virologists alike. Recent studies of RF-encoding genes that combine molecular evolutionary analysis with functional assays illustrate the potential for asking questions ab

有特色

Interplay Between DNA Tumor Viruses and the Host DNA Damage Response, engagement is a result of the genetic linkage between the oncogenic potential of these viruses and their ability to replicate. Namely, the promotion of cells from quiescence into the cell cycle to facilitate virus replication can be sensed through aberrant cellular DNA replication structures which

出汗

Chromatic

思考才皺眉

Roles of MicroRNAs in the Life Cycles of Mammalian Viruses,o the replication of hepatitis C virus, and miRNAs as an experimental tool to control virus replication and vector transgene expression. In the final part of this chapter, I will give a brief overview of virally encoded microRNAs.

CORE

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