| 書目名稱 | Integration of Metabolism, Energetics, and Signal Transduction | | 副標題 | Unifying Foundations | | 編輯 | Robert K. Ockner | | 視頻video | http://file.papertrans.cn/469/468864/468864.mp4 | | 圖書封面 |  | | 描述 | Complex and unexplained phenomena tend to foster unorthodox perspectives. This publication is an example, as is a prior publication that emphasized the concept that intermediary metabolism might play a significant and determining role in hepatocyte proliferation and 1 tumorigenesis. Formulation of this hypothesis was based on an attempt to clarify several poorly understood phenomena; including the observations: 1) that xenobiotic peroxisome proliferators such as the fibrate hypolipidemic agents induce hepatocyte proliferation and carcinogenesis in rodents; 2) that benign and malignant liver tumors complicate the human syndrome of glycogen storage disease type I (glucose-6-phosphatase deficiency); and 3) that in this same syndrome, administration of glucose exerts an anti-tumor effect. Fatty acid and glucose metabolism are tightly linked in a we- established and profoundly inportant interplay. This connection, together with the fact that peroxisome proliferator-induced hepatocyte proliferation and carcinogenesis reflects inhibition of mitochondrial carnitine palmitoyltransferase-I and fatty acid oxidation, suggested the possibility that regulation of fatty acid metabolism could prov | | 出版日期 | Book 2004 | | 關(guān)鍵詞 | Alzheimer; gene expression; metabolism; neurology; proteins | | 版次 | 1 | | doi | https://doi.org/10.1007/b112607 | | isbn_ebook | 978-0-306-48529-9 | | copyright | Springer Science+Business Media New York 2004 |
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