Titlebook: Information for a Better World: Shaping the Global Future; 17th International C Malte Smits Conference proceedings 2022 The Editor(s) (if a

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of the AP site via a hydrolytic mechanism and hence catalyze the initial step in AP site repair (reviewed in .,.,.. A number of DNA glycosylases exhibit AP site-cleavage activity as part of their mechanism of action. However these enzymes act as β-elimination catalysts, cleaving the phosphodiester

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Jeongwon Jo,Tiffany Knearem,Chun-hua Tsai,John M. Carrollmutant cell lines and the construction of mouse knockouts of genes implicated in homologous recombination. This chapter discusses basic parameters of DSB repair by homologous recombination in mammalian cells and emerging evidence for the involvement of various proteins in the repair process.

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Xin Qian,Douglas W. Oard,Joel Chans is an essential handbook for novice and experienced researchers in a variety of fields, including molecular and cellular biology, experimental and clinical pathology, toxicology, radiobiology, oncology, embry978-1-4939-6198-6978-1-60327-409-8Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Elke Greifeneder,Paulina Bressels is an essential handbook for novice and experienced researchers in a variety of fields, including molecular and cellular biology, experimental and clinical pathology, toxicology, radiobiology, oncology, embry978-1-4939-6198-6978-1-60327-409-8Series ISSN 1064-3745 Series E-ISSN 1940-6029