Titlebook: Immunotoxicity, Immune Dysfunction, and Chronic Disease; Rodney R. Dietert,Robert W. Luebke Book 2012 Springer Science+Business Media, LLC

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從容

Cutaneous Allergiescant challenge is how to replace in vivo methods with non-animal alternatives. This issue is given added significance via consideration of the clinical information, where the reality is that, despite useful toxicology methods, the burden of the disease remains substantial, with some contact allergies being at hyperendemic levels.

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Immune Dysfunction in Autism Spectrum Disorders number of candidate genes that link immune function with ASD. Collectively these findings point to a pivotal role for immune-dysregulation in the pathogenesis of ASD. A better understanding of the involvement of the immune response on early brain development and how this is altered in ASD will have important therapeutic implications.

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Atherosclerosis and Inflammatory Heart Diseaseg myocarditis, systemic lupus erythematosus, and rheumatoid arthritis. Although many autoimmune diseases are more prevalent in women, the risk for developing CVD remains elevated in men. Future studies should examine sex differences in CVD biomarkers following infection and/or toxicant exposure.

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COPD and Other Inflammatory Diseases of the Lung: Focus on AhR Signalingg in lung diseases such as chronic obstructive pulmonary disorder, idiopathic fibrosis, Sarcoidosis, acute respiratory distress syndrome, and silicosis. Finally, we address the therapeutic potential of targeting the AhR—IL-22 axis in regulating immunity, inflammation, and tissue homeostasis in lung diseases.

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