Titlebook: Immunogenicity of Biopharmaceuticals; Marco van de Weert,Eva Horn M?ller Book 2008 Springer-Verlag New York 2008 Biosimilar.drug.interfero

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Case Study: Immunogenicity of Interferon-Beta,d therapies with recombinant human IFN-beta. As autoAbs, they neutralize wild-type IFN-beta, they cross-react with both currently used IFNbeta biopharmaceuticals, but not IFN-alpha, and they interfere with biological and immunometric assays for IFN-beta in vitro and in vivo. Although anti- IFN-beta

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sue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless

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Book 2008harmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen

Offensive

Cask Theory Based Parameter Optimization for Particle Swarm Optimization it is desired to get an adaptive optimization method to search a good set of parameters. A nested optimization method is proposed in this paper and it can be used to search the tuned parameters such as inertia weight ., acceleration coefficients c. and c., and so on. This method considers the cask

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DemTectven in the stage of mild cognitive impairment. It covers a wide range of cognitive domains so that it is valid not only for patients with Alzheimer’s disease but also for patients with other types of dementia. DemTect provides cutoff scores for dementia and for cognitive impairment typical of MCI. M

Aboveboard

The Toxicity of Heavy Metals in the Pregnant Woman, Fetus and Newborn Infant,mations during pregnancy had been carried out in the 30-ies and 40-ies, the Thalidomide accident in 1961 is generally accepted as the begin of a new discipline, teratology. Before focusing on the problem of heavy metals in the pre- and perinatal period, the general principles of teratology will brie

Apraxia

Preventive and Personalized Strategies in Ambulatory and Clinical Cardiac Electrophysiology, of atrial fibrillation (AF)—the most common type of arrhythmia—in the form of prolonged continuous electrocardiographic monitoring, exploiting preventive measures and a modern personalized multispecialty team approach for the development of the best diagnostic and therapeutic solutions, certainly w