Titlebook: Hydrophilic Matrix Tablets for Oral Controlled Release; Peter Timmins,Samuel R. Pygall,Colin D. Melia Book 2014 American Association of Ph

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Book 2014ase. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethyl

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PALSY

Applications of Polyethylene Oxide (POLYOX) in Hydrophilic Matrices,nd solubility combinations. Matrices can provide zero-order release profiles for soluble drugs. Long-term stability is aided by inclusion of an antioxidant and judicious choice of fillers at the formulation stage. Various formulation and processing studies are presented in this chapter using model formulation cases.

LIMN

A Formulation Development Perspective on Critical Interactions Affecting the Performance of Hydrophibing these interactions to the extent that is possible from the presented literature. The formulation development scientist should apply these case studies when applicable to prudently assess risks and ensure the successful design of a robust controlled-release drug product.