Titlebook: Human Cytomegaloviruses; Methods and Protocol Andrew D. Yurochko,William E. Miller Book 2014 Springer New York 2014 cytomegalovirus.fibrobl

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Fluorescence-Based Laser Capture Microscopy Technology Facilitates Identification of Critical In ViInfection of these cells results in a predictable transcriptional program leading to high levels of virus production. Infection of other, so-called, nonpermissive cell types results in a transcriptional program that either fails to produce virus particles or production is substantially reduced compa

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What We Have Learned from Animal Models of HCMV,ty. As a member of the betaherpesvirus family, in vivo studies of HCMV are limited due to its species specificity. CMVs from other species are often used as surrogates to express HCMV genes/proteins or used as models for inferring HCMV protein function in humans. Using innovative experiments, these

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Rodent Models of Congenital Cytomegalovirus Infection,sequelae. High rates of sequelae following congenital HCMV infection and insufficient antiviral therapy in the perinatal period make the development of an HCMV-specific vaccine a high priority of modern medicine. Due to species specificity of HCMV, animal models are frequently used to study CMV path

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,Approaches for the Generation of New Anti-cytomegalovirus Agents: Identification of Protein–Proteinor cause of viral-associated congenital malformations in newborn children. The few drugs licensed for anti-HCMV therapy suffer from many drawbacks and none of them have been approved for the treatment of congenital infections. Furthermore, the emergence of drug-resistant viral strains represents a m

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Techniques for Characterizing Cytomegalovirus-Encoded miRNAs,variety of techniques to further characterize miRNAs, their expression, and function. In this chapter, we will discuss techniques currently used in the miRNA field to express, detect, and inhibit miRNAs as well as methods used to identify their targets.

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1064-3745 ation advice from the experts.Includes supplementary materia.With the significant medical role that human cytomegalovirus plays in human disease (from acute disease following primary infection, to chronic disease due to life-long viral persistence), the need to better understand human cytomegaloviru