Titlebook: Hepatocytes; Methods and Protocol Patrick Maurel Book 2010 Humana Press 2010 Cryopreservation.Detoxication.Drug/xenobiotic metabolism and t

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Reversible Manipulation of Apoptosis Sensitivity in Cultured Hepatocytes by Matrix-Mediated Manipuled that hepatocytes cultured as monolayers on dried stiff collagen dedifferentiate, loosing specialized liver functions. In contrast, softer matrix systems like gelled collagen help to preserve these structural and functional features. We show that the de-differentiation process induced in conventio

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Markers and Signaling Factors for Stem Cell Differentiation to Hepatocytes: Lessons from Developmenlist is exceeding the number of available livers for transplantation. Hepatocytes differentiated in vitro from stem cells are a promising and renewable source of tissue for transplantation. The principles guiding programmed differentiation of stem cells to hepatocytes are largely based on knowledge

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Hepatic Stem Cells,n tissue renewal. However, new studies of liver regeneration, hepatocarcinogenesis, liver transplantation, and various cell lines have shown that a variety of cell types participate in maintaining hepatocyte number and mass and question the dogma of the previous hierarchy of hepatocyte differentiati

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Cytokines

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Transdifferentiation of Pancreatic Cells to Hepatocytes,n alternative cellular therapy to orthotopic liver transplantation for the treatment of hepatic failure and hereditary liver disease. To overcome the problem of organ shortage, additional source of hepatocytes must be found. Here, we present a strategy and protocol to transdifferentiate (or convert)

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,Evaluation of Drug Metabolism, Drug–Drug Interactions, and In Vitro Hepatotoxicity with Cryopreservystems is based on the known species–species differences in drug properties. Human-specific drug properties, by definition, cannot be defined using nonhuman experimental animals and therefore can be only assessed in the preclinical phase of drug development using in vitro human-based experimental sy