Titlebook: Hematopoietic Growth Factors in Oncology; Basic Science and Cl George Morstyn,MaryAnn Foote,Graham J. Lieschke Book 2004 Springer Science+B

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Johan F. Vansteenkiste MD, PhD,Christophe A. Dooms MDverter are determined relatively to the maximum permissible load voltage and the control pulse width. Regime change and correspondence between various regime parameters are examined as projective transformations. That makes possible to validate the regime definition, to restrict the range of their v

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Marcie R. Tomblyn MD,Jane N. Winter MDer is interpreted as an affine (for voltage and current) transformation and as a projective (for conductance) transformation. As it was shown in Chap.?., such transformations possess the invariants in the form of an affine ratio of three points and a cross-ratio of four points accordingly. Therefore

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Introduction to Hematopoietic Growth Factorsre precursor cells to functional mature blood cells. The earliest cells are stem cells and are multipotential and able to self-renew. Up to 10. blood cells are produced in an adult human each day. The proliferation of precursor cells, the commitment to one lineage, the maturation of these cells into

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The Jak-Stat Pathway of Cytokine Signalingtors of cytokine signaling. Binding of cytokines to their cognate receptors activates downstream signaling pathways and induces biologic responses. The plethora of cytokines that exhibit common structural motifs and use common receptor subunits and signaling pathways supports the notion of a highly

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Small-Molecule and Peptide Agonists susceptibility to proteolytic degradation, poor membrane penetration, antigenicity, high cost of production, and unfavorable pharmacokinetics can make them less than ideal drug candidates. Furthermore, the poor bioavailability of the native proteins requires that they be administered parenterally.

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Granulocyte Colony-Stimulating Factorls). In keeping with the functions of both G-CSF and neutrophils, the murine molecule was first purified from medium that had bathed the dissected lungs of animals previously treated with a bacterial cell-wall extract .. Several years later, the equivalent human molecule was reported in the supernat

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Erythropoietic Factors .. It was not until 1977, however, that Miyake et al. . isolated human erythropoietin (HuEPO) from the urine of severely anemic patients. Although preparation of the pure hormone allowed amino-acid sequencing of small EPO peptide fragments, it wasn’t until 1983, with the use of unique probing strat

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Thrombopoietin Factorserythropoietin (EPO) regulates erythrocyte production .,.. Despite almost 40 years of research efforts, TPO was finally purified in 1994 by five separate groups using several approaches. Two of the research groups purified the molecule directly from the plasma of thrombocytopenic mice . or sheep . u