Titlebook: Handbook of Schizophrenia Spectrum Disorders, Volume I; Conceptual Issues an Michael S. Ritsner Book 2011 Springer Science+Business Media B

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Irving Gottesman and the Schizophrenia Spectrum,imes increased risk of schizophrenia compared to offspring of only one schizophrenic parent and suggested some kind of genetic overlap with bipolar disorder. In molecular genetics his concept of endophenotypes as interforms between the genotype and its phenotypical manifestations, influenced by epig

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Schizotypy: Reflections on the Bridge to Schizophrenia and Obstacles on the Road Ahead to Etiology tutionalization effects. However, the major stumbling block in the road ahead for schizotypy research, at all levels of analysis, is the problem of heterogeneity. Heterogeneity is observed across symptom pictures, performance patterns on laboratory tasks, longitudinal course, and, probably, at the l

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One Hundred Years of Insanity: Genomic, Psychological, and Evolutionary Models of Autism in Relatioenes underlying under-development versus dysregulated over-development of human social-brain phenotypes. The primary practical implications of these results are that: (1) false-positive diagnoses of premorbidity to schizophrenia-spectrum conditions as autistic spectrum conditions may be common, and

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Quantifying the Dynamics of Central Systemic Degeneration in Schizophrenia,bic systemic degeneration is triggered by environmental stress acting on a pre-existing vulnerability, so that the prefrontal-limbic system can be considered a quantifiable dynamical system evolving under external perturbations. We propose that a nonlinear systems analysis could best address the com

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,Amino Acids in Schizophrenia – Glycine, Serine and Arginine,es in mutant mice in which D-serine levels are altered by manipulating catabolic or anabolic enzymes suggest that inhibitors of D-amino acid oxidase (DAO), particularly in combination with D-serine, may represent a useful future therapeutic approach to the treatment of schizophrenia. Arginine, a pre

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