Titlebook: Handbook of Neurotoxicity; Richard M. Kostrzewa Reference work 2022Latest edition Springer Nature Switzerland AG 2022 Neurotoxicity.Neurto

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Dopamine Homeostasis and Role of VMAT2 in Neurodegenerations, including Parkinson’s disease, schizophrenia, and psychoses. As catecholamines are reactive molecules, metabolic turnover of dopamine is tightly regulated by its synthesis, degradation, and compartmentalization. Vesicular monoamine transporter 2 (VMAT2) sequesters dopamine into synaptic vesicles,

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6-Hydroxydopamine Lesioning of Dopamine Neurons in Neonatal and Adult Rats Induces Age-Dependent Cony into the brain. Refinements in the use of 6-OHDA led to the development of dopamine (DA)-denervated rats to model Parkinson’s disease (PD) and Lesch-Nyhan syndrome (LNS), in which loss of DA-containing neurons is a prominent feature. Differing functional characteristics were eventually discovered

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Reference work 2022Latest editionand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners includi