Titlebook: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics; William D. Figg,Howard L. McLeod Book 20041st edition Humana Press 2004 DNA.

Restenosis

精密

Cytochrome P450 and Anticancer Drugs,on, reduction, and hydrolysis, effected by introducing a polar group into the parent molecule. The phase I reactions are followed by conjugations with hydrophilic compounds such as glucuronic acid and glutathione, to yield a more hydrophilic metabolite (phase II reactions). Cytochrome P450 (P450 or

護(hù)航艦

nugatory

Drug Interactions,nt reviews .. Most patients receive multidrug combinations for their malignancy. Also, many of these patients are treated with intercurrent medication for co-morbidity or for cancer-related disorders (coagulopathy, infection, pain, seizures, etc.). The clinical significance of these potential drug i

Prognosis

ABC Transporters, studied, although host factors and host-tumor interactions may also play critical roles. Cellular resistance mediated by a reduced accumulation of chemotherapy can be due to the expression of drug transporters in tumor cells. The ATP-binding cassette (ABC) transporters, the largest transporter fami

POWER

Intrathecal Chemotherapy,itis or intraparenchymal metastases, is in part due to the pharmacologic sanctuary created by the blood-brain (BBB) and blood-cerebrospinal fluid (CSF) barriers. As a result, tumor cells within the CNS are protected from the cytotoxic effects of systemically administered chemotherapy. Leukemias and

注視

Use of Microdialysis in Preclinical and Clinical Development of Anticancer Agents,nd to initial treatment or relapse after an initial response .. Thus, there is a need to identify factors associated with lack of response and to develop new treatment strategies that address those factors. The development of effective chemotherapeutic agents for the treatment of solid tumors depend

明智的人

Transbarrier Ion and Fluid Transport,eaths in 2020, even if the current trends remain unchanged .. Since the use of mustine to treat a patient with acute lymphoblastic leukemia in 1943 ., 92 anticancer drugs have been approved by the U.S. Food and Drug Administration (FDA). A recent World Health Organization (WHO) consultation consider

四指套

The Vertebrate IntegumentVolume 1entury. Although 92 approved anticancer drugs are available today for the treatment of more than 200 different tumor entities, effective therapies for most of these tumors are lacking .. Out of the 92 registered drugs, 17 are considered by oncologists to be more broadly applicable and 12 additional

Spinal-Tap

The Vertebrate Integument Volume 2l proliferation either in tissue culture (in vitro) or in animals (in vivo), without specific reference to a molecular or cellular target of action. Indeed, the potentially useful effects of the vast majority of agents currently approved for use as safe and effective as oncologic therapeutics in hum