Titlebook: Hair Cell Regeneration; Mark E. Warchol,Jennifer S. Stone,Richard R. Fay Book 2023 Springer Nature Switzerland AG 2023 injury signals.sens

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https://doi.org/10.1007/978-1-349-00218-4the brain of information on sound, so functioning SGNs are necessary both for normal hearing and for the restoration of hearing with cochlear prostheses. This chapter provides a brief introduction to SGNs and their peripheral and central connections. Then, we summarize three types of SGN pathology a

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Juliette Bridgette Milner-Thorntonapid pace. Notably, this work has identified significant roadblocks that prevent hair cell regeneration from occurring naturally in the inner ears of mature mammals. It appears that manipulation of multiple genes, likely combined with alterations of epigenetic modifications, will be needed to stimul

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Cell Junctions and the Mechanics of Hair Cell Regeneration,oud sounds, ototoxic drugs, and aging. Birds, fish, and amphibians recover hearing and vestibular function after hair cell loss, as neighboring supporting cells retain a lifelong capacity to divide and differentiate into replacement hair cells. In mammals, supporting cell plasticity declines sharply

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Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors,lian cochlear HCs do not naturally regenerate after damage. This chapter describes the development of both HCs and their surrounding supporting cells (SCs) from common cochlear progenitor cells. SCs are of specific interest as they are proximal to the HCs, participate in HC regeneration in non-mamma

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