Titlebook: Genomic Instability and Cancer Metastasis; Mechanisms, Emerging Chris Maxwell,Cal Roskelley Book 2015 Springer International Publishing Swi

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,Otologische R?ntgendiagnostik,tumor. These drivers of evolution can generate successful metastatic cells that either survive as dormant cells, or thrive as secondary tumors during the time course of the disease. The metastatic target is thus dynamic, requiring a dynamic approach to treatment. Here we will discuss the growing inf

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Therapie der depressiven Zustandsbilder,ffers selective advantages to the tumor, the tumor-specific loss of these pathways may provide therapeutic opportunities, which could be personalized through knowledge of the specific types of genomic instability that characterize an individual’s tumor.

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Karl-Heinz Huhnstock,Werner Kutschafluencing these levels. We emphasize ionizing radiation, which is the principal environmental factor that increases DSB levels. Mathematical models associating a mutation probability for each DSB have been used to explain the dose dependence of cancer incidence observed after exposure to high doses

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https://doi.org/10.1007/978-3-663-14645-2ition, these approaches are highly specific and restricted to tumor cells, and are expected to decrease side effects associated with current strategies. Both synthetic genetic approaches have been applied extensively in pre-clinical studies and numerous candidate drug targets have been identified, i

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1568-2102 s of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.978-3-319-35295-4978-3-319-12136-9Series ISSN 1568-2102 Series E-ISSN 2215-1648