Titlebook: Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors; C. Marescaux,M. Vergnes,R. Bernasconi Conference proceedings 1992 Springer

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Responses to N-methyl-D-aspartate are enhanced in rats with Petit Mal-like seizures, first study, the changes in extracellular concentration of calcium elicited through ionophoretic application of NMDA at various depths in the cortex were measured in vivo. The results show that in the cortex of epileptic rats the NMDA responses are much more widely distributed than in the cortex of

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Possible mechanisms underlying hyperexcitability in the epileptic mutant mouse tottering,ngs from hippocampal slices in vitro we found that the postsynaptic excitability (firing threshold) of pyramidal neurons in the CA. area of tg/tg slices was significantly higher than that of normal slices. In spite of this hyperexcitability, in vitro epileptiform discharges were not observed spontan