Titlebook: Gene Therapy for Cancer; Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swis Book 2007 Humana Press 2007 angiogenesis.apoptosis.cancer trea

領(lǐng)導(dǎo)權(quán)

Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectorsthe use of RNA viruses as oncolytic agents in the treatment of malignant disease, focusing on the negative-stranded RNA virus, VSV. The general mechanisms by which oncolytic viruses such as VSV achieve their antitumor effectiveness and specificity are discussed, including the role of the innate immune system involving the interferon response.

欺騙世家

勉強(qiáng)

Metamorphosis

Intact

壓碎

Gene Silencing Therapy Against Cancerloped into therapeutics for cancer by selectively silencing aberrantly activated oncogenes. However, major challenges of delivery, specificity and efficacy need to be overcome before siRNAs can be used as therapeutic agents.

松雞

Oncolytic Herpes Simplex for Gene Therapy in Preclinical and Clinical Trialsting the viral genome to more specifically target tumor cells, to further enhance efficacy while maintaining safety, and to assess the role of oncolytic HSV in combination with chemotherapy and radiation therapy.

KIN

知識(shí)分子

Monica S. Cyrino,Meredith E. Safranes. Both preclinical and clinical studies have indicated that restoring the normal function of these genes may be an effective means of cancer therapy although full realization of any anticancer benefit will depend on effective delivery of these genes to cancer cells.

藝術(shù)